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These agents have been shown to reduce inflammation and oxidative stress by downregulating C1q, TNF-a and IL-1a, which are key contributors to neurodegenerative processes in the retina and optic nerve, the authors wrote

In scar tissue, you don't just need new collagen, you need the old, disorganized collagen removed and replaced

Therefore, targeting the products of those genes in the context of a malignant phenotype could produce synthetic lethality (7, 8)

In a parallel study utilizing the HL-60 cell line, evidence emerged suggesting a link between the proliferative effect of AKR1C3 and the retinoic acid signaling pathway